The Dachang tin-polymetallic district, Guangxi, China, is one of the largest tin ore fields in the world. Both cassiterite-sulfide and Zn-Cu skarn mineralization are hosted in the Mid-Upper Devonian carbonate-rich sediments adjacent to the underlying Cretaceous Longxianggai granite (91-97 Ma). The Lamo Zn-Cu deposit is a typical skarn deposit in the district and occurs at the contact zone between the Upper Devonian limestone and the granite. The ore minerals mainly consist of sphalerite, arsenopyrite, pyrrhotite, galena, chalcopyrite, and minor molybdenite. However, the age of mineralization and source of the metals are not well constrained. In this study, we use the molybdenite Re-Os dating method and in-situ Pb isotopes of sulfides from the Lamo deposit for the first time in order to directly determine the age of mineralization and the tracing source of metals. Six molybdenite samples yielded a more accurate Re-Os isochron age of 90.0 ± 1.1 Ma (MSWD = 0.72), which is much younger than the reported garnet Sm-Nd isochron age of 95 ± 11 Ma and quartz fluid inclusions Rb-Sr isochron age of 99 ± 6 Ma. This age is also interpreted as the age of Zn-Cu skarn mineralization in the Dachang district. Further, in this study we found that in-situ Pb isotopes of sulfides from the Lamo deposit and feldspars in the district’s biotite granite and granitic porphyry dikes have a narrow range and an overlap of Pb isotopic compositions (206Pb/204Pb = 18.417-18.594, 207Pb/204Pb = 15.641-15.746, and 208Pb/204Pb = 38.791-39.073), suggesting that the metals were mainly sourced from Cretaceous granitic magma. [ABSTRACT FROM AUTHOR]