Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling.
- Resource Type
- Article
- Authors
- Sandor, Frantisek; Latz, Eicke; Re, Fabio; Mandell, Leisa; Repik, Galina; Golenbock, Douglas T.; Espevik, Terje; Kurt-Jones, Evelyn A.; Finberg, Robert W.
- Source
- Journal of Cell Biology. 9/15/2003, Vol. 162 Issue 6, p1099-1110. 12p. 1 Color Photograph, 1 Chart, 6 Graphs.
- Subject
- *CELL receptors
*NF-kappa B
*CELLULAR signal transduction
- Language
- ISSN
- 0021-9525
Discusses the importance of extra- and intracellular domains of toll-like receptor (TLR) family of proteins in nuclear factor kappabeta (NFkB) signalling. Blocking of cytokine production in peripheral blood mononuclear cells stimulated with ligands AraLAM and tripalmitoyl cysteinyl lipopeptide; Colocalization of TLR1 with TLR2 inside and on the surface of cells; NFkB signal activation requires both TLR1 and TLR2; Distribution pattern of TLR1 overexpression.