• For homogeneous asteroid models, the DART impact outcome is primarily driven by a small number of material properties. • Asteroid porosity and material strength at low pressure have the largest influence on the DART impact outcome. • The momentum enhancement factor in the DART impact is predicted to be ~1.5–2. We present results from numerical simulations of the DART impact using the CTH shock physics code with 2D homogenous asteroid models. A design of experiments approach was used to create a run matrix of 28 simulations varying 17 different material model inputs for the impactor and target. The resulting values of the momentum transfer efficiency factor β and the crater width and depth were analyzed to determine the relative sensitivity of each parameter for predicting the DART impact outcome. We found that β and crater width/depth ratio are primarily influenced by a small number of material model input parameters, a result which greatly reduces the parameter space required for more expensive 3D simulations. [ABSTRACT FROM AUTHOR]