Homozygous HLA‐DQB1*06:02 combined with T‐cell receptor alpha polymorphism results in narcolepsy onset – A familial case report.
- Resource Type
- Article
- Authors
- Jervis, Steven; Payton, Antony; Verma, Arpana; Thomasson, Rachel; Poulton, Kay
- Source
- International Journal of Immunogenetics. Jun2024, Vol. 51 Issue 3, p187-191. 5p.
- Subject
- *T-cell receptor genes
*NARCOLEPSY
*GENETIC disorders
*GENETIC markers
*HEREDITY
*T cells
- Language
- ISSN
- 1744-3121
Narcolepsy is a life‐long neurological disorder with well‐established genetic risk factors. Human leukocyte antigen‐DQB1*06:02 remains the strongest genetic predeterminant; however, polymorphisms in genes encoding the T‐cell receptor alpha chain are also strongly linked. This case report shows the inheritance pathway of these genetic markers contributing to narcolepsy onset in a 17‐year‐old female. [ABSTRACT FROM AUTHOR]