Interaction between hypertension and periodontitis.
- Resource Type
- Article
- Authors
- Ozmeric, Nurdan; Elgun, Serenay; Kalfaoglu, Duygu; Pervane, Beste; Sungur, Çağlar; Ergüder, İmge; Yavuz, Yasemin
- Source
- Oral Diseases. Apr2024, Vol. 30 Issue 3, p1622-1631. 10p.
- Subject
- *PERIODONTITIS treatment
*SALIVA analysis
*RESEARCH funding
*HYPERTENSION
*GINGIVA
*ENZYME-linked immunosorbent assay
*DESCRIPTIVE statistics
*EXUDATES & transudates
*COMPARATIVE studies
*PERIODONTITIS
*INTERLEUKINS
*C-reactive protein
*BIOMARKERS
*DISEASE risk factors
*DISEASE complications
- Language
- ISSN
- 1354-523X
Objective: The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)‐6 and C reactive protein (CRP) levels. Methods: Forty‐two healthy individuals without any previously diagnosed systemic disease [10 periodontally healthy (control) and 10 periodontitis (CP)] and subjects with hypertension [13 periodontally healthy (HP) and 9 with periodontitis (CP + HP)] participated in the study. GCF and saliva samples were obtained at baseline and 4 weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA. Results: Before the periodontal treatment, significantly higher GCF IL‐6 and CRP levels were detected in CP + HP and CP groups compared to HP and control groups (p < 0.01). Salivary CRP level in CP + HP group was found to be higher than the control group (p < 0.05). Statistically significant gingival and plaque index measurements (p < 0.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices; however, biochemical parameters did not change after the treatment. Conclusion: The association of hypertension with periodontitis through local salivary and GCF inflammatory mediators might be possible in disease process. [ABSTRACT FROM AUTHOR]