I DDX41 i mutations, however, escape these criteria because patients bearing these germline mutations develop MDS/AML at similar age as patients with sporadic MDS. Familial clustering of myeloid malignancies with autosomal dominant (AD) inheritance was firstly recognized in 1999 by the identification of germline mutations associated with familial platelet disorders and predisposition to myeloid malignancies [[1]]. Finally, in addition to the consistent number of known germline mutations associated with mesothelioma [[15]] this family indicates the hypothetical role for a DDX41 gene germline variant in mesothelioma origin. Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies. [Extracted from the article]