Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis.
- Resource Type
- Article
- Authors
- Alshammari, Abdulsalam; Patel, Jayesh; Al‐Hashemi, Jacob; Cai, Bin; Panek, James; Huck, Olivier; Amar, Salomon
- Source
- Journal of Clinical Periodontology. Nov2017, Vol. 44 Issue 11, p1123-1132. 10p. 3 Diagrams, 4 Graphs.
- Subject
- *KAVA plant
*PERIODONTITIS treatment
*PORPHYROMONAS gingivalis
*COLLAGEN
*IMMUNOGLOBULINS
*ALVEOLAR process
*WOUNDS & injuries
*THERAPEUTICS
*BIOLOGICAL models
*INFLAMMATION
*PREVENTION
- Language
- ISSN
- 0303-6979
Aim The aim of this study was to evaluate the effect of Kava-241, an optimized Piper methysticum Kava compound, on periodontal destruction in a collagen antibody primed oral gavage model of periodontitis. Methods Experimental periodontitis was induced by oral gavage of Porphyromonas gingivalis ( P. gingivalis) + type II collagen antibody ( AB) in mice during 15 days. Mice were treated with Kava-241 concomitantly or prior to P. gingivalis gavage and compared to untreated mice. Comprehensive histomorphometric analyses were performed. Results Oral gavage with P. gingivalis induced mild epithelial down-growth and alveolar bone loss, while oral gavage with additional AB priming had greater tissular destruction in comparison with gavage alone ( p < .05). Kava-241 treatment significantly ( p < .05) reduced epithelial down-growth (72%) and alveolar bone loss (36%) in P. gingivalis+ AB group. This Kava-241 effect was associated to a reduction in inflammatory cell counts within soft tissues and an increase in fibroblasts ( p < .05). Conclusion Priming with type II collagen antibody with oral gavage is a fast and reproducible model of periodontal destruction adequate for the evaluation of novel therapeutics. The effect of Kava-241 shows promise in the prevention and treatment of inflammation and alveolar bone loss associated with periodontitis. Further experiments are required to determine molecular pathways targeted by this therapeutic agent. [ABSTRACT FROM AUTHOR]