This article discusses a case of atypical epidermolytic palmoplantar keratoderma (EPPK), a rare hereditary skin condition. The patient, an 8-year-old boy, presented with diffuse hyperkeratosis on his palms, soles, and other areas of his body. Genetic analysis revealed a mutation in the KRT1 gene, which is associated with EPPK and other skin conditions. Ultrastructural analysis of the patient's skin showed abnormal keratin structures, suggesting that atypical EPPK is a minimal phenotypic variant of epidermolytic ichthyosis (EI). The study also suggests that non-genetic factors and inflammatory cytokines may contribute to the development of these skin diseases. [Extracted from the article]