Chemoenzymatic synthesis of antiviral carbocyclic nucleosides: Asymmetric hydrolysis of...
- Resource Type
- Article
- Authors
- Tanaka, Masakazu; Norimine, Yoshihiko
- Source
- Journal of Organic Chemistry. 10/4/96, Vol. 61 Issue 20, p6952. 6p. 1 Chart.
- Subject
- *NUCLEOSIDES
*BIOSYNTHESIS
- Language
- ISSN
- 0022-3263
Reports on the preparation of meso-3,5-bis(acetoxymethyl)cyclopentenes with the bulky substituent at the C-4 position from 7-substituted norbornadiene. Further hydrolysis of compounds by Rhizopus delemar lipase to the monoalcohols in an enantioselective manner; Conversion of optically active alcohols into the anti-HIV active carbocyclic nucleosides.