Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibα promoter: in vivo model for platelet-targeting gene therapy.
- Resource Type
- Article
- Authors
- Ohmori, Tsukasa; Mimuro, Jun; Takano, Katsuhiro; Madoiwa, Seiji; Kashiwakura, Yuji; Ishiwata, Malta; Niimura, Masanori; Mitomo, Katsuyuki; Tabata, Toshiaki; Hasegawa, Mamoru; Ozawa, Keiya; Sakata, Yoichi
- Source
- FASEB Journal. Jul2006, Vol. 20 Issue 9, p1522-1524. 3p. 1 Diagram, 2 Graphs.
- Subject
- *TRANSGENE expression
*BLOOD platelets
*GENE therapy
*HEMOPHILIA
*BLOOD diseases
- Language
- ISSN
- 0892-6638
Develops a technique for efficient transgene expression in platelets in vivo and examines whether this targeted-gene-product delivery system using the platelet release reaction was directly applicable to gene therapy for coagulation deficiency hemophilia A. Comparison of luciferase reporter expression driven by platelet-specific promoters; Life span of megakaryocytes; Description of hemophilia A.