Anti-tubercular therapy (ATT) drugs are the mainstay of management of tuberculosis worldwide. These medicines are used extensively across the globe in treating tubercular infections of any organ. The life-threatening complications of pseudomembranous enterocolitis (PMC) associated with ATT, especially with capsule Rifampicin is not known to most practitioners. An early suspicion during the onset of loose stools in a patient on ATT is essential for managing this life-threatening condition. This fatal case report is to create awareness among the healthcare professionals and sensitize the clinicians, about the possibility of PMC in patients on ATT. We discuss our case and the lessons learnt in this case report. [ABSTRACT FROM AUTHOR]