Earlier it was reported that in a donor with ALS carrying a I C9orf72 i mutation, dipeptide pathology was present in the retina in the absence of TDP-43 pathology [[2]]. The absence of pTDP-43 positive aggregates in AD with limbic TDP-43 depositions suggests that the occurrence of TDP-43 aggregates in the retina relates to the severity of TDP-43 pathology in the brain, since within these limbic cases the TDP-43 pathology remains localized. In this study, we observed no TDP-43 inclusions in the retina of 2 ALS donors without cortical TDP-43 depositions or AD patients with limbic TDP-43 pathology, suggesting that retinal TDP-43 pathology reflects the cortical involvement of TDP-43 aggregation. We also included donors with FTLD-tau ( I n i = 5), FTLD-FUS ( I n i = 1), AD with limbic-predominant age-related TDP-43 depositions (LATE) ( I n i = 2) and without ( I n i = 1), donors with ALS due to TDP-43 (ALS-TDP ( I n i = 2)) and neurologically healthy controls ( I n i = 6). [Extracted from the article]