This study systematically investigated patients with diabetes, chronic heart pain, and lower limb bone fractures based on pharmacology and radiology. Osteoporosis or osteoporosis is actually a disease in which bone mass is low and its tissue is weak and subsequently becomes very fragile. This disease is the most common metabolic bone disease. Osteoporosis is very common in postmenopausal women and 30% of them suffer from fractures caused by this problem. Osteoporosis is a painless disease until a fracture occurs. This disease is usually diagnosed after a bone fracture, especially in the areas of the neck of the femur and lumbar vertebrae. Therefore, the absence of pain does not mean the absence of osteoporosis. Severe osteoporosis may be present even without pain with a fracture. Fracture in such conditions can happen even by itself or with mild trauma cases such as a simple fall. In addition to old age and menopause, other factors can act as a risk factor for osteoporosis, including some underlying diseases and medications. Among these diseases that because secondary osteoporosis is diabetes (type 1 and 2), hyperthyroidism, hyperparathyroidism, pregnancy, smoking and alcohol consumption, malnutrition, chronic liver and kidney disease, vitamin D deficiency, AIDS, hemophilia and Arthritic rheumatism and... Diabetes is a common disease with a clear connection between type 1 and osteoporosis. Diabetes is the most common metabolic disease, characterized by increased blood sugar, impaired carbohydrate, fat and protein metabolism, and as a result, defects in insulin secretion or insulin action are created. The chronic nature of diabetes affects the patient's body, mind, and personal and social functioning. Diabetes is a serious public health problem that threatens the quality of life of patients and can lead to acute and chronic complications and is an important cause of disability and death in many countries. [ABSTRACT FROM AUTHOR]