MicroRNA-494 inhibits the growth and angiogenesis-regulating potential of mesenchymal stem cells.
- Resource Type
- Article
- Authors
- Chen, Shiwen; Zhao, Guangfeng; Miao, Huishuang; Tang, Ruijing; Song, Yuxian; Hu, Yali; Wang, Zhiqun; Hou, Yayi
- Source
- FEBS Letters. Mar2015, Vol. 589 Issue 6, p710-717. 8p.
- Subject
- *MICRORNA
*NEOVASCULARIZATION inhibitors
*PREECLAMPSIA
*MESENCHYMAL stem cells
*VASCULAR endothelial growth factors
*CELL growth
- Language
- ISSN
- 0014-5793
Mesenchymal stem cells (MSCs) play an important role in the pathology of preeclampsia (PE). Our previous microarray analysis found that microRNA-494 (miR-494) is highly expressed in decidua-derived MSCs (dMSCs) from PE. We hypothesized that aberrant expression of miR-494 in dMSCs is involved in PE development. In the present study, we found that miR-494 arrests G1/S transition in dMSCs by targeting CDK6 and CCND1. We also found that supernatant from miR-494-overexpressing dMSCs reduces HTR-8/SVneo migration and impairs HUVEC capillary formation by suppressing VEGF. Taken together, we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE. [ABSTRACT FROM AUTHOR]