An efficient and green process for the synthesis of 5-methyl-2-nitrobenzoic acid.
- Resource Type
- Article
- Authors
- Mei, Wenyi; Yao, Sen; Yu, Mingjun; Yao, Risheng
- Source
- Research on Chemical Intermediates. Apr2018, Vol. 44 Issue 4, p2751-2759. 9p. 3 Diagrams, 3 Charts, 4 Graphs.
- Subject
- *ENVIRONMENTAL chemistry
*NITROBENZOIC acid
*ORGANIC synthesis
*NITRATION
*REGIOSELECTIVITY (Chemistry)
- Language
- ISSN
- 0922-6168
A new and environmental friendly nitration process of methyl 3-methylbenzoate by mixtures of HNO3/Ac2O for the synthesis of 5-methyl-2-nitrobenzoic acid has been developed. In this strategy, the key process is the nitration of methyl 3-methylbenzoate. The main advantages of this procedure are that it utilized a high selectivity of substrates and a green nitrating process. This made control of the reaction rate much easier. [ABSTRACT FROM AUTHOR]