Asymmetric Synthesis of Homoallylic Amines Bearing Adjacent Stereogenic Centers by Addition of Substituted Allylic Zinc Reagents to N-tert-Butanesulfinylimines.
- Resource Type
- Article
- Authors
- Leleti Rajender Reddy; Bin Hu; Mahavir Prashad; Kapa Prasad
- Source
- Organic Letters. May2008, Vol. 10 Issue 14, p3109-3112. 4p.
- Subject
- *ORGANIC compounds
*ORGANIC synthesis
*AMINES
*ZINC
- Language
- ISSN
- 1523-7060
A highly diastereoselective addition of substituted racemic allylic zinc reagents to chiral N- tert-butanesulfinylimines resulting in the formation of homoallylic amines is reported. This method is quite general and also efficient for the preparation of enantiomerically pure homoallylic amines bearing quaternary centers and also adjacent quaternary centers. [ABSTRACT FROM AUTHOR]