The article discusses the use of predeposit autologous donation (PAD) in transfusion medicine. It highlights that PAD should only be used for patients with rare blood groups or multiple blood group antibodies where compatible allogeneic blood is difficult to obtain. The article also addresses recent concerns about the COVID-19 vaccination status of donors and emphasizes that PAD is not recommended for conscientious objections to donor blood. Preoperative autologous donation (PAD) is no longer recommended in obstetric practice due to the risks and potential complications involved. The article mentions various risks and concerns associated with PAD, such as errors in labeling and storage, donor anemia, wastage rates, and the need for fixed timings. It suggests alternative options like cell salvage and tranexamic acid. The guidelines recommend patient counseling, involvement of stakeholders, and adherence to blood regulations. Overall, PAD is rarely appropriate and should be carefully evaluated on a case-by-case basis. [Extracted from the article]