Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis.
- Resource Type
- Article
- Authors
- Dong, Haiyan; Lu, Bo; Wang, Jie; Xie, Jingjing; Liu, Kuancan; Jia, Lee; Zhuang, Junyang
- Source
- Chemical Communications. 12/21/2019, Vol. 55 Issue 98, p14797-14800. 4p.
- Subject
- *CANCER genes
*DNA
*SINGLE nucleotide polymorphisms
*CANCER diagnosis
- Language
- ISSN
- 1359-7345
We propose a novel fluorescence assay method by designing a polymerization-driven DNA dominoes collapse (PDDC) strategy, enabling highly sensitive detection of p53 gene (as a model analyte) and single nucleotide polymorphism analysis. [ABSTRACT FROM AUTHOR]