Exploring the potential role of oxidative stress‐related genes in colorectal cancer recurrence and establishing a recurrence assessment system based on single‐cell and bulk RNA‐seq analysis.
- Resource Type
- Article
- Authors
- Gao, Xin; Li, Jin; Wang, Qing‐Yu; Wang, Zi‐Hui; Li, Si‐Jia; Zeng, Lv‐Tao; Liu, Hong‐Lei; Cai, Jian‐Ping
- Source
- Clinical & Translational Medicine. Feb2024, Vol. 14 Issue 2, p1-8. 8p.
- Subject
- *COLORECTAL cancer
*CANCER genes
*REGULATORY T cells
*MYELOID-derived suppressor cells
*MEDICAL sciences
*CANCER relapse
- Language
- ISSN
- 2001-1326
This article discusses a study that investigated the role of oxidative stress and related genes in the recurrence of colorectal cancer (CRC). The study identified 22 recurrence-related genes and categorized patients into two distinct subtypes based on their gene expression. Significant differences were observed in immune cell infiltration levels and recurrence between the subtypes. The study also analyzed the intratumoral microbiome and found that lower microbiome diversity was associated with patient recurrence. A 6-gene signature was developed to predict recurrence risk, and a nomogram was created to facilitate the prediction of CRC recurrence. The study provides insights into the potential clinical utility of oxidative stress-related genes in CRC recurrence. [Extracted from the article]