ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats.
- Resource Type
- Article
- Authors
- Zhang, Chao; Kong, Xiaohong; Liu, Chang; Liang, Zhipin; Zhao, Huabing; Tong, Wei; Ning, Guangzhi; Shen, Wenyuan; Yao, Liwei; Feng, Shiqing
- Source
- Biochemical & Biophysical Research Communications. Feb2014, Vol. 444 Issue 3, p395-400. 6p.
- Subject
- *MITOGEN-activated protein kinases
*SMALL interfering RNA
*FIBROSIS
*COLLAGEN
*GENE expression
*INFLAMMATION
*LAMINECTOMY
*LABORATORY rats
- Language
- ISSN
- 0006-291X
Highlights: [•] Lentiviral vector construction and virus packaging. [•] Lentiviral ERK2 siRNA detection both in vitro and vivo. [•] Lentiviral ERK2 siRNA is able to prevent collagen expression and scar adhesion. [•] Lentiviral ERK2 siRNA is able to suppress the expression of TGF-β1 and IL-6. [ABSTRACT FROM AUTHOR]