This article provides guidelines for the laboratory diagnosis and monitoring of von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS). It emphasizes the importance of accurate and standardized laboratory testing for reliable results. The article recommends specific tests, such as measuring factor VIII activity, VWF antigen, and VWF activity, for the initial investigation of VWD/AVWS. It also discusses the use of genetic testing to complement clinical and laboratory findings. The guidelines outline methodologies for genetic testing and stress the need for informed consent and accurate reporting of results. [Extracted from the article]