Glioblastom Multiforme (GBM) is the most invasive and malignant member of the IV grade of the subclass Astrocytoma according to the last assessment of the 2016 WHO report. Due to the resistance to treatment and weak response, as well as the topographical structure of the blood brain barrier, which is a major part of malignant brain tumors, treatment is also difficult due to the severe clinical manifestation, and new treatment methods and new therapeutic agents are needed. Conventional treatment methods are surgical resection, radiotherapy and chemotherapy. Median survival time is 12.5 months in patients. Glucose metabolism is a complex energy producing machine that generates energy and stores it as ATP and provides energy for all cellular processes. A glucose molecule produces 38 molecules of ATP after full glycolytic catabolism. According to Otto Warburg's numerous studies and basic hypothesis, cancer metabolism is completely different from normal cells. Cancer cells tend to the anaerobic phenotype only by performing the first glycolytic step without entering the mitochondrial step. As a result, these cells produce lactic acid and make the secretions and micro-media even more acidic in aerobic conditions. This phenomenon is attributed to the Warburg hypothesis and either as anaerobic glucolysis. Although glycolysis enzymes are the primary actors of this phenotypic expression, some genetic and epigenetic factors are no exception. For this reason, we experimentally used KC7F2 active ingredient to target cancer metabolism. As a result of our experience, we observed that the effect of the KC7F2 suppresses aerobic glycolysis and has significant effects on several metabolism genes. [ABSTRACT FROM AUTHOR]