Purpose: to present the results of “Gamma-knife” radiosurgery (GKRS) of diffuse choroidal hemangioma (DCH) in patients with Sturge-Weber syndrome Methods: Four patients (4 eyes) with DCH were managed with GKRS. There were 2 males and 2 females aged 6, 15, 16 and 32 y.o. All patients were presented with port-wine stains of the face. Visual acuity (VA) before treatment was poor in every case due to exudative total retinal detachment and varied from 0.002 to 0.006 (mean 0.005). The choroidal thickness was from 5.1 mm to 7.3 mm (mean 5.8mm). The height of the retinal detachment was measured from 2.5 to 6.6 mm (mean 4.95mm). GKRS was proposed as the last opportunity to save the eye and provide any VA degree. The dosimetry plans included double PTVs of 18 Gy sparing critical structures – optic nerve and central retina. Optic nerve received 8.9-20Gy (mean 14.24Gy), central retina – 13-28.8Gy (mean 20.5Gy). Results: Tumor activity control was achieved in all cases. The choroidal thickness reduced to 3.2-4.5mm (mean 3.8 mm) within 3 months, to 2.1-4.4mm within 6 months. Choroidal thickness decreased by 44% on average (34-50%). Retinal detachment resolution was seen in every treated eye that provided the VA of 0.02 – 0.4 (mean 0.15). No tumor progression was detected and no additional treatment was required. All eyes under follow-up are stable from 3 to 40 months. Irradiation “tracks” corresponding to the planning are seen on the eye fundus examination and will be presented. No complications were detected within follow-up period. Conclusion: There is no effective conventional treatment of DCH in patients with Sturge-Weber syndrome. GKRS may be used as the single opportunity to save the eye and provide any kind of vision. Further investigation is needed. [ABSTRACT FROM AUTHOR]