Interleukin-17 receptor expression on vascular endothelial cells of masses of skeletal extramedullary disease in myeloma patients.
- Resource Type
- Article
- Authors
- Yang, Jian-Zhu; Li, Yan; Sun, Li-Xia; Fang, Jie; Kong, Ling-Juan; Zhang, Jin-Qiao
- Source
- Pathology - Research & Practice. Sep2014, Vol. 210 Issue 9, p586-590. 5p.
- Subject
- *INTERLEUKIN-17
*CANCER patients
*CELL receptors
*GENE expression
*VASCULAR endothelial cells
*BONE diseases
- Language
- ISSN
- 0344-0338
The goal of the study was to investigate the expression of interleukin-17 (IL-17) and IL-17 receptor (IL-17R) in patients with myeloma bone diseases (MBD) and skeletal extramedullary disease (skeletal EMD). The levels of IL-17 were determined using ELISA. The expression of IL-17R on vascular endothelial cells of bone marrow (BM) and masses of skeletal EMD was detected using immunohistochemistry. The results showed an elevated IL-17 level in BM of BMD and skeletal EMD patients. The microvessel density (MVD) was significantly increased in the masses of skeletal EMD. IL-17R was almost exclusively expressed by endothelial cells, not by myeloma cells in the masses of skeletal EMD patients. We concluded that EMD masses showed increased angiogenesis mediated by IL-17 pathway and in part this may help in myeloma cell-growth under these conditions. [ABSTRACT FROM AUTHOR]