Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans.
- Resource Type
- Article
- Authors
- Ruaud, Anne-Françoise; Katic, Iskra; Bessereau, Jean-Louis
- Source
- Genetics. Jan2011, Vol. 187 Issue 1, p337-343. 7p.
- Subject
- *SOMATOMEDIN
*CAENORHABDITIS elegans
*INSULIN
*NEMATODES
*GROWTH
- Language
- ISSN
- 0016-6731
Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/ Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation. Our studies provide further evidence for broad conservation of insulin/insulin-like growth factor (IGF) functions in developmental speed control. [ABSTRACT FROM AUTHOR]