Simple Summary: Increasing demand for genetic testing and counseling among families with hereditary cancers has drawn attention to the genetic skills and knowledge of healthcare professionals (HCPs). However, many HCPs face challenges regarding confidence in communicating genetic risk to their patients and accessing genetic training programs. Developing genomic educational strategies and standardizing the curriculum for HCPs is critical to improving genetic care. This systematic review identified the learning needs of HCPs and compared them across professions, along with their perspectives on essential information for families affected by hereditary cancer. While HCPs recognized the importance of providing a wide range of information to families affected by hereditary cancer and emphasized enhancing practical counseling skills, their learning needs varied by profession. Our findings have implications for developing training programs for HCPs, underscoring the importance of developing targeted training programs and resources aligned with their specific profession. Background: The increased demand for genetic testing and counseling necessitates healthcare professionals (HCPs) to improve their genetic competency through training programs. This systematic review identified HCPs' learning needs and their perspectives on essential information for families with hereditary cancer. Methods: This review covered studies published from 2013 to 2024 across five databases. Data were analyzed using a content analysis. Results: Thirteen studies involving 332 HCPs were analyzed. Most studies focused on the learning needs of physicians caring for families affected by Hereditary Breast and Ovarian Cancer in North America and Europe. HCPs required training emphasizing practical counseling skills over the basics of genetics. Learning needs varied by profession: physicians needed training in assessing cancer risk and supporting decision-making in risk management; nurses required information on resources and the genetic care system; genetic counselors sought guidance on family communication and planning. Essential information identified for families included risk-reducing strategies, personalized cancer risk assessment, family implications, psychological issues, (cascade) genetic testing, and social concerns. Conclusions: The findings have implications for the development of training programs for HCPs, emphasizing the need for tailored training based on professions. Future research should explore the needs of HCPs caring for families with diverse hereditary cancers and cultural backgrounds. [ABSTRACT FROM AUTHOR]