Pre-existing type 2 diabetes at the time of planning pregnancy and in pregnancy In principle, type 2 diabetes mellitus is associated with the same fetal risks as type 1 diabetes mellitus. Lifestyle Accompanying drug therapy in type 2 diabetes and pregnancy, the lifestyle recommendations generally applicable to diabetes, as well as the general recommendations for weight gain in pregnancy dependent on pre-conceptional weight, should also be followed. The spectrum of malformations associated with maternal diabetes (type 1 diabetes/type 2 diabetes) includes, in particular, congenital heart defects (2.3-4%, approximately 4-fold increased compared to women without diabetes), neural tube defects (1.2-2.5%, 2- to 3-fold increased), skeletal anomalies, omphaloceles, malformations of the urinary tract, and biliary atresia with splenic anomalies [32][33][34][35]. Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes. [Extracted from the article]