Progressive multifocal leukoencephalopathy in patients with chronic liver disease successfully treated with pembrolizumab.
- Resource Type
- Article
- Authors
- Jeantin, Lina; Shor, Natalia; Coustans, Marc; Roos-Weil, Damien; Quintin-Roué, Isabelle; Bellanger, Agnès; Le Garff-Tavernier, Magali; Ben Jemaa, Rahma; Thabut, Dominique; Pourcher, Valérie; Weiss, Nicolas
- Source
- Journal of Neurology. Apr2024, Vol. 271 Issue 4, p2119-2124. 6p.
- Subject
- *JOHN Cunningham virus
*PROGRESSIVE multifocal leukoencephalopathy
*CHRONICALLY ill
*TREATMENT effectiveness
*T-cell exhaustion
*PEMBROLIZUMAB
- Language
- ISSN
- 0340-5354
This document discusses the potential use of pembrolizumab as a treatment for progressive multifocal leukoencephalopathy (PML) in patients with chronic liver disease. PML is a serious infection of the central nervous system typically observed in individuals with severe immunosuppression. The document presents two cases in which PML progression was halted with pembrolizumab treatment, resulting in improvement and regression of PML lesions. The article emphasizes the challenges faced by clinicians in diagnosing and treating PML in patients with liver disease and highlights the need for more evidence to support the use of pembrolizumab in PML treatment. [Extracted from the article]