Keywords: speech; calcium; tics; language EN speech calcium tics language 627 630 4 05/04/21 20210501 NES 210501 Primary brain calcification syndromes are heterogeneous disorders characterized by pathological peri-microvascular calcium deposition in the basal ganglia, subcortical white matter, thalamus and cerebellum.1 Most are inherited in an autosomal dominant fashion ( I SLC20A2 i , I XPR1, PDGFRB i , I PDGFB i ), though recently, biallelic variants in the I MYORG i and I JAM2 i genes have been identified as autosomal recessive causes of the syndrome.2,3 Clinical manifestations are protean. In adults without a past history of tic disorder, or in the presence of other abnormal features on neurological examination, tic-like vocalizations should raise concern for underlying neurodegenerative disorders. These peak in incidence in late childhood/early adolescence, particularly in males, and can be self-limiting (transient/provisional tic disorder, lasting<12 months) or persistent, either as chronic tics (which generally ease with age) or Tourette's syndrome. [Extracted from the article]