MARVELD1 regulates integrin β1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing.
- Resource Type
- Article
- Authors
- Wang, Shan; Hu, Jianran; Yao, Yuanfei; Shi, Ming; Yue, Lei; Han, Fang; Zhang, Hao; He, Jie; Liu, Shanshan; Li, Yu
- Source
- International Journal of Biochemistry & Cell Biology. Nov2013, Vol. 45 Issue 11, p2679-2687. 9p.
- Subject
- *INTEGRINS
*CELL adhesion
*CYTOSKELETON
*PHOSPHORYLATION
*MESSENGER RNA
*FOCAL adhesion kinase
- Language
- ISSN
- 1357-2725
Highlights: [•] MARVELD1 delays cell spreading and regulates actin cytoskeleton organization. [•] Integrin β1 is down-regulated in MARVELD1 over-expressing cells. [•] MARVELD1 negatively affects phosphorylation level of FAK at Tyr397. [•] MARVELD1 inhibits pre-mRNA processing of integrin β1. [ABSTRACT FROM AUTHOR]