Because of a high clearance rate and low recurrence rate, 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has now been reported as an effective treatment option for condyloma acuminatum (CA) patients in China.[[1]] However, during the course of ALA-PDT, most patients experience burning and tingling pain that affects the treatment efficacy and patient's satisfaction.[[3]] Therefore, effective pain reduction strategies during ALA-PDT are required. In conclusion, our findings demonstrated that pregabalin combined with ALA-PDT is a safe and less painful therapeutic option for CA patients, and pregabalin will provide an effective way to alleviate the pain during ALA-PDT. As an antiepileptic drug, pregabalin has long been used in the management of acute and chronic pain conditions,[5] but it is not yet known whether pregabalin effectively and safely relieves pain in CA patients during ALA-PDT. [Extracted from the article]