Adverse Effects Under Th2 Biologics (Dupilumab and Tezepelumab) in a Patient with Severe Asthma and Atopic Dermatitis.
- Resource Type
- Article
- Authors
- Suhling, Hendrik; Hinze, Christopher Alexander; Welte, Tobias; Werfel, Thomas; Traidl, Stephan
- Source
- Respiration. Dec2023, Vol. 102 Issue 12, p1016-1019. 4p.
- Subject
- *DRUG therapy for asthma
*BIOTHERAPY
*THERAPEUTIC use of monoclonal antibodies
*STEROID drugs
*THRUSH (Mouth disease)
*PAIN
*MICROSCOPY
*HETEROCYCLIC compounds
*STEROIDS
*MONOCLONAL antibodies
*ADRENAL insufficiency
*EXANTHEMA
*SEVERITY of illness index
*DYSPNEA
*ATOPIC dermatitis
*HOSPITAL care
*DRUG side effects
*ALLERGIES
*OINTMENTS
*TERMINATION of treatment
*HYDROCORTISONE
*MICROBIAL sensitivity tests
*SYMPTOMS
- Language
- ISSN
- 0025-7931
Introduction: This is the first report of a patient with severe asthma and atopic dermatitis that developed local perioral skin infection which onset coincided with the patient's treatment with dupilumab (candida albicans) and later with tezepelumab (microscopic detection of yeast). Case Presentation: Besides moderate headache, macular exanthema was found after administration of tezepelumab, which was subsequently accompanied by a worsening of symptoms upon reexposure to the treatment. Both sensations needed multidisciplinary treatment and both antibody therapies were stopped. [ABSTRACT FROM AUTHOR]