Previously developed kinetic anddynamic models of the hydroformylationof 1-dodecene in a thermomorphic multicomponent solvent system (TMS),consisting of DMF, n-decane, and hydroformylationproducts, were experimentally validated applying various operationmodes, such as batch, semibatch, and perturbed batch operation. Onthe basis of experimentally obtained data, which cover a broad rangeof physical conditions, the parameters of the reaction kinetics wererefined to give reliable model predictions as basis for rigorous processoptimization. The improved model was used for dynamic optimizationto obtain optimal trajectories (e.g., temperature and gas dosing fluxesversus reaction time), which maximize the selectivity to the desiredlinear aldehyde product. The predicted optimal trajectories were successfullyvalidated in semibatch reactor experiments. [ABSTRACT FROM AUTHOR]