A Practical Two-Step Synthesis of 3-Alkyl-2,3-dihydro-1H-isoindolin-1-ones.
- Resource Type
- Article
- Authors
- Ruan, Yuan‐Ping; Chen, Ming‐De; He, Ming‐Zhu; Zhou, Xiang; Huang, Pei‐Qiang
- Source
- Synthetic Communications. 2004, Vol. 34 Issue 5, p853-861. 9p. 1 Diagram, 1 Chart.
- Subject
- *GRIGNARD reagents
*CHEMICAL reagents
*ALKYLATION
*BIOACTIVE compounds
*HYDROCARBONS
*CHEMICAL reactions
- Language
- ISSN
- 0039-7911
A flexible approach to 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones via the reductive-alkylation procedure is described. Present method is versatile in scope, allowing the easy introduction of various C-3 carbon-substituents by Grignard addition to phthalimide. [ABSTRACT FROM AUTHOR]