The co-evolution of microorganisms with multi cellular mega-organisms and the influence of the microbiome on the health of larger partners is a trending area in current research. The ratio of bacterial cells to human cells is an ongoing study in the field of human health. From 10 : 1, bacteria to human cell ratio, to 1 : 1 is the current information. However, after carefully perusing the emerging data of human and bacterial cells, we propose an out-of-box hypothesis of the golden ratio, 1.618, to be in the evolutionary cellular arrangements between the bacteria and human cells. If proved, it could pave way for better preparedness in managing human health using the microbiome, with the possibility of its spillover into plant health management too. [ABSTRACT FROM AUTHOR]