Facile preparation of a controlled-release tubular scaffold for blood vessel implantation.
- Resource Type
- Article
- Authors
- Guo, Xuran; Zhu, Jingjing; Zhang, Hongmei; You, Zhengwei; Morsi, Yosry; Mo, Xiumei; Zhu, Tonghe
- Source
- Journal of Colloid & Interface Science. Mar2019, Vol. 539, p351-360. 10p.
- Subject
- *CHINESE medicine
*CONTROLLED release drugs
*VASCULAR surgery
*SILICA nanoparticles
*PHASE separation
- Language
- ISSN
- 0021-9797
Graphical abstract Abstract Salvianic acid-loaded mesoporous silica nanoparticles into gelatin/polyurethane bilayered small-diameter tubular scaffold were prepared by thermally induced phase separation (TIPS) and electrospinning. Mesoporous silica nanoparticles (MSNs) were selected as carriers to load salvianic acid (SAL). The SAL-loaded MSNs (SAL@MSNs) with an optimized SAL loading efficiency of 10% was initially dispersed in gelatin solution and under a vacuum freeze-drying process as an inner layer of vascular scaffolds. Then, poly(ester-urethane)urea (C-PEEUU) nanofibers were electrospun outside the SAL@MSNs/Gelatin vascular scaffold to strengthen the spongy matrix. The loaded SAL within the MSNs/Gelatin/C-PEEUU bilayered small-diameter tubular scaffold showed a sustained release profile and good mechanical properties. In addition, the drug-loaded composite scaffold showed no unfavorable effects on the adhesion and proliferation of endothelial cells. Moreover, no intimal hyperplasia and acute thrombosis was observed in the short-term implantation in rabbit's carotid artery. We believe the SAL@MSNs/Gelatin/C-PEEUU bilayered vascular scaffolds have promise for vascular tissue engineering applications. [ABSTRACT FROM AUTHOR]