Genetically Determined Height and Coronary Artery Disease.
- Resource Type
- Article
- Authors
- Nelson, C. P.; Hamby, S. E.; Saleheen, D.; Hopewell, J. C.; Zeng, L.; Assimes, T. L.; Kanoni, S.; Willenborg, C.; Burgess, S.; Amouyel, P.; Anand, S.; Blankenberg, S.; Boehm, B. O.; Clarke, R. J.; Collins, R.; Dedoussis, G.; Farrall, M.; Franks, P. W.; Groop, L.; Hall, A. S.
- Source
- New England Journal of Medicine. 4/23/2015, Vol. 372 Issue 17, p1608-1618. 11p.
- Subject
- *CORONARY heart disease risk factors
*HEIGHT measurement
*GENETICS
*CARDIOVASCULAR diseases
*CARDIOVASCULAR system
- Language
- ISSN
- 0028-4793
The article presents a study on the mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD). It used a genetic approach to investigate the association between height and CAD using 180 height-associated genetic variants. It was shown that the primary association between a genetically determined shorter height and an increased risk of CAD was partly due to the association between shorter height and an adverse lipid profile.