The COVID−19 pandemic may have uniquely impacted families of children in cancer treatment. Primary caregivers (N = 47) completed validated measures of COVID−19 exposure, impact, and psychosocial distress between July 2020 and January 2021. Caregivers reported several pandemic-related disruptions to daily life (COVID−19 exposure) and a negative impact of the pandemic on caregiver mood (70%) and anxiety (72%). A subset of caregivers reported a positive impact of the pandemic on physical wellbeing and family functioning. Family psychosocial distress was associated with higher COVID−19 exposure but not COVID−19 impact. Results highlight family resilience as well as groups with unmet psychosocial needs. [ABSTRACT FROM AUTHOR]