Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model.
- Resource Type
- Article
- Authors
- Albrecht, Mark T.; Eyles, Jim E.; Baillie, Les W.; Keane-Myers, Andrea M.
- Source
- FEMS Immunology & Medical Microbiology. Aug2012, Vol. 65 Issue 3, p505-509. 5p. 1 Chart, 2 Graphs.
- Subject
- *IMMUNOGENETICS
*ANTHRAX
*DNA vaccines
*BACILLUS anthracis
*YERSINIA pestis
*PLAGUE
*LABORATORY mice
- Language
- ISSN
- 0928-8244
The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor ( LFn) fused to either Yersinia pestis V antigen ( V) or Y. pestis F1 was evaluated. A/ J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis. [ABSTRACT FROM AUTHOR]