New Voltammetric Approach to the Quantitation of Paracetamol in Tablets and Syrup using Chemometric Optimization Technique.
- Resource Type
- Article
- Authors
- Remziye Güzel; Ekşi, Haslet; Dinç, Erdal; Solak, Ali Osman
- Source
- Journal of Analytical Chemistry. Mar2019, Vol. 74 Issue 3, p296-305. 10p.
- Subject
- *POLYANILINES
*MATHEMATICAL optimization
*ACETAMINOPHEN
*GOLD nanoparticles
*DRUG tablets
*ELECTROLYTIC reduction
- Language
- ISSN
- 1061-9348
A new voltammetric approach was developed for the determination of paracetamol in tablet and syrup samples using chemometric optimization. The method is based on the use of the gold nanoparticles–polyaniline (AuNPs−PA) modified pencil graphite electrode (PGE). Electrode system was fabricated by using the electrochemical reduction of gold on aniline modified pencil electrode to give gold nanoparticles. A 33 full factorial design was used to find optimal oxidation conditions of paracetamol on the AuNPs−PA−PGE. The optimal oxidation conditions of drug substance were found as –524 mV for the accumulation potential, 295 s for the accumulation time and pH 8.69 (for the phosphate buffer solution, 0.1 M). The determination of paracetamol was linear in the range of 2.0 × 10–7–6.0 × 10–6 M with a detection limit of 5 × 10–8 M. As a result, the proposed voltammetric approach gave satisfactory results for the determination of the related drug substance in tablets and syrup. [ABSTRACT FROM AUTHOR]