Evaluation of Xpert® BCR‐ABL Ultra for the confirmation of BCR‐ABL1 international scale conversion factors for the molecular monitoring of chronic myeloid leukaemia.
- Resource Type
- Article
- Authors
- Dominy, Katherine M.; Simon, Iris M.; Sorouri‐Khorashad, Jamshid
- Source
- International Journal of Laboratory Hematology. Feb2021, Vol. 43 Issue 1, pe31-e34. 4p.
- Subject
- *POLYMERASE chain reaction
*CHRONIC myeloid leukemia
*REVERSE transcriptase polymerase chain reaction
- Language
- ISSN
- 1751-5521
The article discusses research which evaluated the Xpert® BCR-ABL Ultra assay developed by Cepheid for confirming the breakpoint cluster region protein (BCR)-tyrosine-protein kinase (ABL1) fusion gene conversion factors (CF). Topics explored include the use of CF data for monitoring of Philadelphia positive chronic myeloid leukaemia (CML), comparison between this platform and a real-time polymerase chain reaction assay, and the BCR-ABL1 transcript results generated by the Xpert assay.