Introduction: Mexico was the first country in the Americas and the third in the world to eliminate trachoma as a public health problem, as validated by the WHO in 2017. Objective: To describe the critical elements that favored the elimination of trachoma as a public health problem in Mexico and the public health impact of this success. Methodology: A revision and compilation of data and information contained in the dossier presented by the country to PAHO/WHO to obtain the validation of trachoma elimination as a public health problem was conducted by a group of delegates from the national and local trachoma prevention and control program. Data from the national and local surveillance systems and reports of actions conducted after achieving the elimination goal were also included. Critical elements that favored the achievement of the elimination goal from 1896 to 2019 were extracted. Results: Mexico reached the elimination of trachoma in 2016 obtaining the validation in 2017. 264 communities were no longer endemic and 151,744 people were no longer at risk of visual impairment or possible blindness due to trachoma. The key to the success of this elimination process was primarily the local leadership of health authorities with sustained funding for brigades, increased access to potable water and sanitation, and key alliances with indigenous authorities, health authorities, and government institutions that contributed to the achievement of the goal. The SAFE strategy started implementation in Mexico in 2004 as a comprehensive package of interventions. SAFE stands for surgery, antibiotics, facial cleanliness, and improvement of the environmental conditions. These actions impacted drastically on the number of new cases trachmatous trichiasis (TT) and trachomatous inflammation-follicular (TF), which decreased from 1,794 in 2004 to zero in 2016. Conclusions: The elimination of trachoma as a public health problem in Mexico is a true success story that may serve as a model example for the elimination of other neglected infectious diseases in the Americas. Author summary: Trachoma is an eye disease caused by an infection with Chlamydia trachomatis. It is the principal infectious cause of irreversible blindness worldwide and is one of the 20 neglected tropical diseases which is present in 1,338 districts worldwide with an estimated 154.5 million people living in endemic areas. Globally, the disease was earmarked for elimination as a public health problem by the year 2020 and later extended to the year 2030. The WHO elimination strategy SAFE includes Surgery, Antibiotics, Facial cleanliness, and Environmental improvement. This paper describes the SAFE activities implemented and actions taken for Mexico to achieve the elimination of trachoma as a public health problem. From the compilation of national and local data and information, it was possible to identify that local and federal political commitment and leadership, effective coordination across health institutions and critical sectors such as water and sanitation agencies, and consistent communication and health promotion activities that supported the implementation of SAFE strategies were determinant in driving trachoma elimination. The model of coordinated work and collaboration serves as a model example for the elimination of trachoma and other Neglected Infectious Diseases in Latin America. [ABSTRACT FROM AUTHOR]