Presented here are three case studies that demonstrate the breadth of bulk actinide analytical chemistry at Los Alamos National Laboratory (LANL). This laboratory was established during the Manhattan Project and is still considered one of the premier analytical laboratories for special nuclear materials characterization around the globe. First, the analytical chemistry of 238Pu is presented, showcasing the unique challenges of this high activity isotope. Next, the analysis of 241AmO2 is discussed from the perspective of supporting nascent production at LANL. Finally, the analytical chemistry support of the production of plutonium non-destructive assay standards is discussed. These examples paint a picture of the analytical capabilities needed to meet the dynamic challenges of LANL's nuclear programs. [ABSTRACT FROM AUTHOR]