Palladium(II)‐Catalyzed Selective Arylation of Tertiary C−H Bonds of Cyclobutylmethyl Ketones Using Transient Directing Groups.
- Resource Type
- Article
- Authors
- Cheng, Jin‐Tang; Xiao, Li‐Jun; Qian, Shao‐Qun; Zhuang, Zhe; Liu, An; Yu, Jin‐Quan
- Source
- Angewandte Chemie. 4/25/2022, Vol. 134 Issue 18, p1-4. 4p.
- Subject
- *ARYLATION
*PALLADIUM
*KETONES
- Language
- ISSN
- 0044-8249
We report the first example of selective PdII‐catalyzed tertiary C−H activation of cyclobutylmethyl ketones using a transient directing group. An electron‐deficient 2‐pyridone ligand was identified as the optimal external ligand to enable tertiary C−H activation. A variety of cyclobutylmethyl ketones bearing quaternary carbon centers was readily accessed without preinstalling internal directing groups in up to 81 % yield and >95 : 5 regioisomeric ratios of tertiary C−H arylation to β‐methylene (β‐methyl) or γ‐C−H arylation. [ABSTRACT FROM AUTHOR]