Diminution of Circulating CD4+CD25 high T cells in naïve Crohn's disease.
- Resource Type
- journal article
- Authors
- Chamouard, Patrick; Monneaux, Fanny; Richert, Zoe; Voegeli, Anne-Claire; Lavaux, Thomas; Gaub, Marie; Baumann, René; Oudet, Pierre; Muller, Sylviane; Gaub, Marie Pierre; Baumann, René
- Source
- Digestive Diseases & Sciences. Oct2009, Vol. 54 Issue 10, p2084-2093. 10p. 6 Charts, 4 Graphs.
- Subject
- *CROHN'S disease
*ULCERATIVE colitis
*T cells
*FLOW cytometry
*CELL populations
*BLOOD cell count
*COMPARATIVE studies
*INTERLEUKIN-2
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*CD4 antigen
*EVALUATION research
*LYMPHOCYTE subsets
- Language
- ISSN
- 0163-2116
Crohn's disease is considered to be caused either by an excess of T-cell effector functions and/or by a defective regulatory T-cell compartment. The aim of this study was to assess in Crohn's disease the frequency of circulating CD4(+)CD25(high) T cells that possess regulatory T-cell functions and CD4(+)CD25(low) T cells that contain activated T cells. Flow cytometry of peripheral blood was used to assess CD4(+)CD25(high) and CD4(+)CD25(low) T-cell frequencies in a cohort of 66 patients with Crohn's disease in comparison to 19 patients with ulcerative colitis and 31 healthy individuals enrolled as controls. The CD4(+)CD25(high) T-cell frequency was significantly lowered in naïve Crohn's disease (P = 0.013) and in ulcerative colitis (P = 0.001). CD4(+)CD25(low) T-cell frequency was increased in Crohn's disease (P = 0.0001) and in ulcerative colitis (P = 0.0002). Both CD4(+)CD25(high) and CD4(+)CD25(low) T-cell frequencies are altered in naïve Crohn's disease resulting in an imbalance between both populations and a relative contraction of the CD4(+)CD25(high) T-cell population. [ABSTRACT FROM AUTHOR]