These patients suffer from the highest socioeconomic burden of AD and not all respond to currently available therapies, including biological agents.1,8 The understanding of the breakdown of the skin microbial ecosystems and how this drives AD development and exacerbation is limited. Atopic dermatitis, S. aureus, bacteriotherapy, skin microbiome, therapy Keywords: atopic dermatitis; bacteriotherapy; S. aureus; skin microbiome; therapy EN atopic dermatitis bacteriotherapy S. aureus skin microbiome therapy 1331 1333 3 03/30/22 20220401 NES 220401 Abbreviations AD atopic dermatitis AIPs autoinducing peptides AMPs antimicrobial peptides CoNS coagulase-negative staphylococci RDBPC randomized double-blind placebo-controlled S. Staphylococcus Sh A9 Staphylococcus hominis A9 Atopic dermatitis (AD) is a common chronic inflammatory skin disease, whose pathophysiology involves a complex interplay of genetic predisposition, environmental factors, immune dysregulation, and altered skin barrier function. [Extracted from the article]