Supramolecular systems chemistry has been an area of active research to develop nanomaterials with life‐like functions. Progress in systems chemistry relies on our ability to probe the nanostructure formation in solution. Often visualizing the dynamics of nanostructures which transform over time is a formidable challenge. This necessitates a paradigm shift from dry sample imaging towards solution‐based techniques. We review the application of state‐of‐the‐art techniques for real‐time, in situ visualization of dynamic self‐assembly processes. We present how solution‐based techniques namely optical super‐resolution microscopy, solution‐state atomic force microscopy, liquid‐phase transmission electron microscopy, molecular dynamics simulations and other emerging techniques are revolutionizing our understanding of active and adaptive nanomaterials with life‐like functions. This Review provides the visualization toolbox and futuristic vision to tap the potential of dynamic nanomaterials. [ABSTRACT FROM AUTHOR]