Developments in ELSD Technology to Improve Sensitivity and Linearity of Response over a Wider Dynamic Range.
- Resource Type
- Article
- Authors
- Cleaver, Graham; Bullock, Steve
- Source
- Chromatography Today. May/Jun2015, Vol. 8 Issue 2, p38-41. 4p.
- Subject
- *CHROMATOGRAPHIC detectors
*LIGHT scattering -- Measurement
*CHROMATOGRAPHIC analysis
*MOLECULAR weights
*LIGHT scattering
*ANALYTICAL chemistry
- Language
- ISSN
- 1752-8070
The article reports on the developments in Evaporating Light Scattering Detector (ELSD) technology to improve sensitivity and linearity of response over a wider dynamic range. It discusses why ELSD has become a popular detector choice for HPLC/UHPLC. It informs that the past limitations of this detector were its limited sensitivity and dynamic range when compared to ultraviolet (UV) detection and it did not perform well with low molecular weight compounds.