Contact sports in which head injuries occur commonly (and also where CTE is most frequently reported) are historically male dominated, and this likely underlies the strong male bias in CTE prevalence to date. In sport, CTE risk appears dose dependent; increasing career length (and, thus, potential for exposure to TBI) correlates with a greater risk of developing CTE, and more severe CTE [[6]]. To the Editor: Chronic traumatic encephalopathy (CTE) is a neuropathological diagnosis of degenerative brain disease characterized by neuronal accumulation of hyperphosphorylated tau (p-tau) around blood vessels at the depths of cortical sulci, with or without thorn-shaped astrocytes [[2]]. [Extracted from the article]