Characterization of adhesive properties of red blood cells using surface acoustic wave induced flows for rapid diagnostics.
- Resource Type
- Article
- Authors
- Sivanantha, Ninnuja; Charles Ma; Collins, David J.; Sesen, Muhsincan; Brenker, Jason; Coppel, Ross L.; Neild, Adrian; Alan, Tuncay
- Source
- Applied Physics Letters. 9/8/2014, Vol. 105 Issue 10, p1-5. 5p. 1 Black and White Photograph, 1 Diagram, 3 Graphs.
- Subject
- *ADHESIVES
*ERYTHROCYTES
*ACOUSTIC surface waves
*GLUTARALDEHYDE
*MALARIA
*CELL populations
*PATIENTS
- Language
- ISSN
- 0003-6951
This letter presents a method which employs surface acoustic wave induced acoustic streaming to differentially peel treated red blood cells (RBCs) off a substrate based on their adhesive properties and separate populations of pathological cells from normal ones. We demonstrate the principle of operation by comparing the applied power and time required to overcome the adhesion displayed by healthy, glutaraldehyde-treated or malaria-infected human RBCs. Our experiments indicate that the method can be used to differentiate between various cell populations contained in a 9 µl droplet within 30 s, suggesting potential for rapid diagnostics. [ABSTRACT FROM AUTHOR]